It’s possible, although notices on Joaquin Phoenix may come into play for Joker.
Arguably Endgame’s best chance at an acting honor will be a more leftfield pick like Karen Gillan, Chris Evans or Bradley Cooper for Rocket. Gillan could be well in contention for a BAFTA for example as the Brits like to vote for one of our own.
To be honest, I think Chris Evans did more in Endgame and Jeremy Renner could also be a leftfield pick as he had to do a lot of heavy lifting as Hawkeye and has a previous couple of nominations.
It’s a crapshoot, but this year we’ve got the best chance ever of a comic book movie being the winner.